Friday, October 25, 2019 RNR, DNA, and Free Radicals
Our guest speaker is JoAnne Stubbe, Novartis Professor of Chemistry, Emeritus at MIT who will discuss the role that ribonucleotide reductases (RNRs) play in catalyzing the conversion of nucleotides to deoxynucleotides in DNA replication and repair.
Free radicals (molecules that have lost an electron and are therefore highly active) are often cited as contributing significantly to the aging process. Recent investigations, however, have shown that certain free radicals play a very beneficial role in biochemistry, and a number of drugs based on this recognition are being developed. A brief overview of the "good" radicals and their involvement in an essential enzyme mediated reaction in primary metabolism will be presented.
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